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      服务热线:18118481917

      脂质体装备

      Extru 25-20台式脂质体挤出仪

      高性价比·高适用性的新型台式脂质体挤出仪

      Extru 25-20台式脂质体挤出仪

      Desktop Liposome Extruder:Extru 25-20


      专利号:2018216111703



      2520E.jpg

      主要应用

      The main application


      阿霉素脂质体 

      Liposome doxorubicin


      两性霉素 B 脂质体 

      Amphotericin B liposome


      紫杉醇脂质体

      Paclitaxel liposomes


      奥沙利铂脂质体

      Oxaliplatin liposomes


      伊立替康脂质体

      Irinotecan liposome


      SiRNA 脂质体

      SiRNA liposome


      白蛋白紫杉醇纳米粒

      Albumin paclitaxel nanoparticles


      核酸类脂质体 

      Nucleic acid liposome


      其他整粒脂质体样品

      Other whole li posome samples


      挤出原理

      Technical features


      脂质体挤出的原理在于大2020欧洲杯下注官网,通过一定的挤出动力源将脂质体样品粒子进行挤压大2020欧洲杯下注官网,使其在一定压力条件下通过 PC滤膜, 此压力作为粒子过膜过程中的剪切力可使其达到粒径控制的效果。不论形态、大小和分布都可得到极大改善。 


      The principle of liposome extrusion is that the particles of liposome sample are extruded by a certain extrusion power source to pass through the PC membrane under a certain pressure. The pressure acts as the shear force in the process of the particles passing through the membrane, which can achieve the effect of particle size control. The shape, size and distribubtion can be greatly improved.


      支撑板和滤板主要起到支撑滤膜的作用。 由于磷脂有一定的相变温度大2020欧洲杯下注官网,所以在挤出之前需要对挤出器夹套通入恒温水进行预热至一定温度(50~60℃),且在使用过程中需保持在此温度。通常的脂质体品种挤出之后粒径能达到 100nm以下,PDI 能控制在 0.1 以下大2020欧洲杯下注官网。


      The support plate and the filter plate mainly play the role of supporting the filter membrane.Because of phospholipids have certain phase change temperature before extrusion need access to extruder jacket thermostatic water preheated to a certain temperature (50 ~ 60 ℃), and needs to keep the temperature in the process of use.The particle size of the normal liposome can reach below 100nm after extrusion, and the PDI can be controlled below 0.1.


      动力源:氮气

      Power source: nitrogen


      技术特征

      Technical features


      核心部件 The core components


      支撑板(SS316L不锈钢)

      Support plate (SS316L stainless steel)


      滤板(SS316L不锈钢)

      Filter plate (SS316L stainless steel)


      滤膜:PC材质(聚碳酸酯)

      Filter membrane :PC material (polycarbonate)


      密封系统:PU材质/聚四氟乙烯

      Sealing system: PU material/polytetrafluoroethylene


      温控系统:夹套控温水

      Temperature control system: jacket control warm water


      技术特点 Technical characteristics


      单次样品量少

      Low sample consumption


      压力高

      High extrusion pressure


      残留量为"0"

      No residue


      无需手动操作

      No manual operation required


      全程可控温

      Whole process temperature control


      所有部件包括“O”型圈,垫圈均通过FDA 认证 

      All parts including "O" rings, gaskets are FDA approved


      装卸方便大2020欧洲杯下注官网,便于清洗和灭菌 

      Easy loading and unloading, easy cleaning and sterilization


      所有数据可直接放大 

      All data can be directly amplified


      可用于高浓度样品处理 

      Can be used for high concentration sample processing


      可放在洁净室中使用,符合 GMP 标准 

      Can be used in a clean room, in line with GMP standards



      型号 MODEL

      Extru 25-20

      最高压力 [Mpa] 

      The highest pressure[Mpa]

      25

      最终产品粒径 [nm]

      Final product size [nm]

      50~1000

      单批处理量[ml]

      The Final product size[ml]

      0~20

      最高产品浓度[mg/ml]

      Maximum product concentration[mg/ml]

      200

      工作温度范围

      Operating temperature range

      5~80℃

      产品材质

      Product material

      SS316L

      直径[mm]

      The diameter of

      25

      动力源类型
      Power source type

      Gas





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      本篇文章原创版权归属:苏州艾特森制药设备有限公司



      大2020欧洲杯下注官网
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